Version 5.4
Homo sapiens Protein: ING1
Summary
InnateDB Protein IDBP-50894.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ING1
Protein Name inhibitor of growth family, member 1
Synonyms p24ING1c; p33; p33ING1; p33ING1b; p47; p47ING1a;
Species Homo sapiens
Ensembl Protein ENSP00000364930
InnateDB Gene IDBG-50886 (ING1)
Protein Structure
UniProt Annotation
Function Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene. {ECO:0000269PubMed:9440695}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. {ECO:0000269PubMed:10866301}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines. {ECO:0000269PubMed:10626813}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 72 [view]
Protein-Protein 65 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 4 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0035064 methylated histone binding
Biological Process
GO:0007049 cell cycle
GO:0008285 negative regulation of cell proliferation
GO:0016568 chromatin modification
GO:0030308 negative regulation of cell growth
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001965 Zinc finger, PHD-type
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger
PFAM PF00628
PRINTS
PIRSF
SMART SM00249
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UK53
PhosphoSite PhosphoSite-Q9UK53
TrEMBL
UniProt Splice Variant
Entrez Gene 3621
UniGene Hs.610356
RefSeq NP_937861
HUGO HGNC:6062
OMIM 601566
CCDS CCDS9518
HPRD 03337
IMGT
EMBL AB024401 AB024402 AB024403 AB024404 AB024405 AB031269 AB037387 AB037594 AF001954 AF044076 AF078835 AF078836 AF078837 AF149721 AF149722 AF149723 AF167549 AF167550 AF167551 AF181849 AF181850 AJ310392 AK302353 AL157820 BC093942 BC093944 CH471085
GenPept AAB60879 AAC00501 AAF07920 AAF07921 AAF37421 AAF37422 AAF37423 AAG02578 AAG02579 AAG12174 AAG12175 AAH93942 AAH93944 BAA82886 BAA82887 BAA82888 BAA82889 BAA82890 BAA83462 BAA83496 BAB08101 BAB08102 BAB08103 BAB20992 BAG63679 CAC38067 CAI16972 CAI16973 CAI16974 CAI16975 EAX09127 EAX09130

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca