InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ING1

Summary

InnateDB Gene

IDBG-50886.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ING1

Gene Name

inhibitor of growth family, member 1

Synonyms

p24ING1c; p33; p33ING1; p33ING1b; p47; p47ING1a

Species

Homo sapiens

Ensembl Gene

ENSG00000153487

Encoded Proteins

IDBP-50888

inhibitor of growth family, member 1

IDBP-50892

inhibitor of growth family, member 1

IDBP-50894

inhibitor of growth family, member 1

IDBP-50896

inhibitor of growth family, member 1

IDBP-809327

inhibitor of growth family, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:110712736-110723339

Strand

Forward strand

Band

q34

Transcripts

ENST00000338450	ENSP00000345202
ENST00000333219	ENSP00000328436
ENST00000375775	ENSP00000364930
ENST00000375774	ENSP00000364929
ENST00000464141	ENSP00000480985

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	72 [view]
Protein-Protein	65 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0035064	methylated histone binding

Biological Process

GO:0006606	protein import into nucleus
GO:0007049	cell cycle
GO:0008285	negative regulation of cell proliferation
GO:0010941	regulation of cell death
GO:0016568	chromatin modification
GO:0030308	negative regulation of cell growth
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000045969

View Gene Order

ENSBTAG00000025211

Not yet available

Cross-References

SwissProt

Q9UK53

TrEMBL

UniProt Splice Variant

Entrez Gene

3621

UniGene

Hs.46700 Hs.610356

RefSeq

NM_005537 NM_001267728 NM_198217 NM_198218 NM_198219

HUGO

HGNC:6062

OMIM

601566

CCDS

CCDS9517 CCDS9515 CCDS9516 CCDS9518

HPRD

03337

IMGT

EMBL

AB024401 AB024402 AB024403 AB024404 AB024405 AB031269 AB037387 AB037594 AF001954 AF044076 AF078835 AF078836 AF078837 AF149721 AF149722 AF149723 AF167549 AF167550 AF167551 AF181849 AF181850 AJ310392 AK302353 AL157820 BC093942 BC093944 CH471085

GenPept

AAB60879 AAC00501 AAF07920 AAF07921 AAF37421 AAF37422 AAF37423 AAG02578 AAG02579 AAG12174 AAG12175 AAH93942 AAH93944 BAA82886 BAA82887 BAA82888 BAA82889 BAA82890 BAA83462 BAA83496 BAB08101 BAB08102 BAB08103 BAB20992 BAG63679 CAC38067 CAI16972 CAI16973 CAI16974 CAI16975 EAX09127 EAX09130

RNA Seq Atlas

3621