Version 5.4
Homo sapiens Protein: PCDH1
Summary
InnateDB Protein IDBP-50919.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCDH1
Protein Name protocadherin 1
Synonyms PC42; PCDH42;
Species Homo sapiens
Ensembl Protein ENSP00000287008
InnateDB Gene IDBG-50917 (PCDH1)
Protein Structure
UniProt Annotation
Function May be involved in cell-cell interaction processes and in cell adhesion.
Subcellular Localization Cell junction. Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.
Disease Associations
Tissue Specificity Highly expressed in the brain and neuro-glial cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007156 homophilic cell adhesion
GO:0007267 cell-cell signaling
GO:0007399 nervous system development
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR002126 Cadherin
IPR013164 Cadherin, N-terminal
IPR013585 Protocadherin
IPR015919 Cadherin-like
PFAM PF00028
PF08266
PF08374
PRINTS PR00205
PIRSF
SMART SM00112
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q08174
PhosphoSite PhosphoSite-Q08174
TrEMBL D6RBG2
UniProt Splice Variant
Entrez Gene 5097
UniGene Hs.79769
RefSeq NP_115796
HUGO HGNC:8655
OMIM 603626
CCDS CCDS4267
HPRD 04692
IMGT
EMBL AC094107 BC035812 CH471062 L11369 L11370
GenPept AAA36418 AAA36419 AAH35812 EAW61902

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca