Version 5.4
Homo sapiens Gene: PCDH1
Summary
InnateDB Gene IDBG-50917.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCDH1
Gene Name protocadherin 1
Synonyms PC42; PCDH42
Species Homo sapiens
Ensembl Gene ENSG00000156453
Encoded Proteins
IDBP-50919
protocadherin 1
IDBP-241390
protocadherin 1
IDBP-473799
protocadherin 1
IDBP-481089
protocadherin 1
IDBP-473502
protocadherin 1
IDBP-478162
protocadherin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracelllular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:141853111-141879246
Strand Reverse strand
Band q31.3
Transcripts
ENST00000287008 ENSP00000287008
ENST00000357517
ENST00000394536 ENSP00000378043
ENST00000503492 ENSP00000424667
ENST00000511044
ENST00000515351 ENSP00000424204
ENST00000505937 ENSP00000424004
ENST00000514773 ENSP00000424163
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007156 homophilic cell adhesion
GO:0007267 cell-cell signaling
GO:0007399 nervous system development
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051375
View Gene Order
ENSBTAG00000012518
Not yet available
Cross-References
SwissProt
TrEMBL D6RAX3 D6RBG2
UniProt Splice Variant
Entrez Gene 5097
UniGene Hs.79769
RefSeq NM_001278613 NM_001278615 NM_002587 NM_032420 XM_005268452 XM_005268453 XM_005268454 XM_005268455 XM_005268456
HUGO HGNC:8655
OMIM 603626
CCDS CCDS4267 CCDS43375
HPRD 04692
IMGT
EMBL AC094107
GenPept
RNA Seq Atlas 5097

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca