InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCGB1A1

Summary

InnateDB Protein

IDBP-50983.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCGB1A1

Protein Name

secretoglobin, family 1A, member 1 (uteroglobin)

Synonyms

CC10; CC16; CCPBP; CCSP; UGB; UP-1; UP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000278282

InnateDB Gene

IDBG-50981 (SCGB1A1)

Protein Structure

UniProt Annotation

Function

Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0019834	phospholipase A2 inhibitor activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007565	female pregnancy
GO:0007566	embryo implantation
GO:0009410	response to xenobiotic stimulus
GO:0010033	response to organic substance
GO:0010193	response to ozone
GO:0032496	response to lipopolysaccharide
GO:0032689	negative regulation of interferon-gamma production
GO:0032696	negative regulation of interleukin-13 production
GO:0032713	negative regulation of interleukin-4 production
GO:0032714	negative regulation of interleukin-5 production
GO:0034021	response to silicon dioxide
GO:0034097	response to cytokine
GO:0042130	negative regulation of T cell proliferation
GO:0042493	response to drug
GO:0043086	negative regulation of catalytic activity
GO:0043488	regulation of mRNA stability
GO:0050727	regulation of inflammatory response
GO:0051384	response to glucocorticoid
GO:0071774	response to fibroblast growth factor

Cellular Component

GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005791	rough endoplasmic reticulum
GO:0030141	secretory granule