InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BTG1

Summary

InnateDB Protein

IDBP-51012.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BTG1

Protein Name

B-cell translocation gene 1, anti-proliferative

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000256015

InnateDB Gene

IDBG-51010 (BTG1)

Protein Structure

UniProt Annotation

Function

Anti-proliferative protein. {ECO:0000269PubMed:1373383}.

Subcellular Localization

Disease Associations

Note=A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with MYC.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	32 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019900	kinase binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0006979	response to oxidative stress
GO:0007283	spermatogenesis
GO:0008285	negative regulation of cell proliferation
GO:0016477	cell migration
GO:0030308	negative regulation of cell growth
GO:0043434	response to peptide hormone
GO:0045603	positive regulation of endothelial cell differentiation
GO:0045663	positive regulation of myoblast differentiation
GO:0045766	positive regulation of angiogenesis
GO:2000271	positive regulation of fibroblast apoptotic process