InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EEA1

Summary

InnateDB Protein

IDBP-51093.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EEA1

Protein Name

early endosome antigen 1

Synonyms

MST105; MSTP105; ZFYVE2;

Species

Homo sapiens

Ensembl Protein

ENSP00000317955

InnateDB Gene

IDBG-51091 (EEA1)

Protein Structure

UniProt Annotation

Function

Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.

Subcellular Localization

Cytoplasm. Early endosome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	41 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005545	1-phosphatidylinositol binding
GO:0008270	zinc ion binding
GO:0030742	GTP-dependent protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0006897	endocytosis
GO:0006906	vesicle fusion
GO:0016189	synaptic vesicle to endosome fusion
GO:0045022	early endosome to late endosome transport

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005769	early endosome
GO:0005829	cytosol
GO:0005969	serine-pyruvate aminotransferase complex
GO:0016020	membrane
GO:0019897	extrinsic component of plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0031901	early endosome membrane
GO:0044308	axonal spine
GO:0055037	recycling endosome
GO:0070062	extracellular vesicular exosome