Version 5.4
Homo sapiens Gene: EEA1
Summary
InnateDB Gene IDBG-51091.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EEA1
Gene Name early endosome antigen 1
Synonyms MST105; MSTP105; ZFYVE2
Species Homo sapiens
Ensembl Gene ENSG00000102189
Encoded Proteins
IDBP-51093
early endosome antigen 1
IDBP-381116
early endosome antigen 1
IDBP-596279
early endosome antigen 1
IDBP-592733
early endosome antigen 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:92770637-92929331
Strand Reverse strand
Band q22
Transcripts
ENST00000322349 ENSP00000317955
ENST00000418984 ENSP00000394312
ENST00000549790 ENSP00000446785
ENST00000547833
ENST00000553019 ENSP00000449682
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 41 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005545 1-phosphatidylinositol binding
GO:0008270 zinc ion binding
GO:0030742 GTP-dependent protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006897 endocytosis
GO:0006906 vesicle fusion
GO:0016189 synaptic vesicle to endosome fusion
GO:0045022 early endosome to late endosome transport
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005969 serine-pyruvate aminotransferase complex
GO:0016020 membrane
GO:0019897 extrinsic component of plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
GO:0044308 axonal spine
GO:0055037 recycling endosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036499
View Gene Order
ENSBTAG00000000421
Not yet available
Pathways
NETPATH
REACTOME
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_6802
Innate Immune System pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_6900
Immune System pathway
KEGG
hsa04144
Endocytosis pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt Q15075
TrEMBL F8VUZ7 F8W119 F8WE79
UniProt Splice Variant
Entrez Gene 8411
UniGene Hs.567367 Hs.606539 Hs.665737
RefSeq NM_003566 XM_006719631
HUGO HGNC:3185
OMIM 605070
CCDS CCDS31874
HPRD
IMGT
EMBL AC016136 AC021646 AC026111 L40157 X78998
GenPept AAA79121 CAA55632
RNA Seq Atlas 8411

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca