InnateDB Protein
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IDBP-51208.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PSMC3IP
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Protein Name
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PSMC3 interacting protein
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000253789
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InnateDB Gene
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IDBG-51206 (PSMC3IP)
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Protein Structure
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Function |
Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1- promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors. {ECO:0000269PubMed:10806355, ECO:0000269PubMed:16407260, ECO:0000269PubMed:21963259}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:11739747}.
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Disease Associations |
Ovarian dysgenesis 3 (ODG3) [MIM:614324]: A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. {ECO:0000269PubMed:21963259}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Highly expressed in testis and colon. {ECO:0000269PubMed:11739747, ECO:0000269PubMed:7490091}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003677
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DNA binding
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GO:0030374
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ligand-dependent nuclear receptor transcription coactivator activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005650
BlaI transcriptional regulatory family
IPR010776
Tat binding protein 1-interacting
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PFAM |
PF03965
PF07106
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PRINTS |
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PIRSF |
PIRSF019455
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9P2W1
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PhosphoSite |
PhosphoSite-Q9P2W1
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TrEMBL |
A0A024R1W9
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UniProt Splice Variant |
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Entrez Gene |
29893
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UniGene |
Hs.383019
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RefSeq |
NP_037422
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HUGO |
HGNC:17928
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OMIM |
608665
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CCDS |
CCDS11431
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HPRD |
16362
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IMGT |
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EMBL |
AB030304
AC067852
AF440240
BC008792
CH471152
FJ952180
FJ952181
FJ952182
FJ952183
GQ851964
GQ851965
L38933
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GenPept |
AAC41915
AAH08792
AAL33609
ACR46655
ACR46656
ACR46657
ACR46658
ACX30903
ACX30904
BAA92872
EAW60849
EAW60850
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