InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE2N

Summary

InnateDB Protein

IDBP-51222.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2N

Protein Name

ubiquitin-conjugating enzyme E2N

Synonyms

HEL-S-71; UBC13; UbcH-ben; UbcH13; UBCHBEN; UBC13;

Species

Homo sapiens

Ensembl Protein

ENSP00000316176

InnateDB Gene

IDBG-51220 (UBE2N)

Protein Structure

UniProt Annotation

Function

The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19340006}. Cytoplasm {ECO:0000269PubMed:19340006}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 231 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	231 [view]
Protein-Protein	224 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0043130	ubiquitin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0000729	DNA double-strand break processing
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006282	regulation of DNA repair
GO:0006301	postreplication repair
GO:0006464	cellular protein modification process
GO:0006508	proteolysis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016567	protein ubiquitination
GO:0016574	histone ubiquitination
GO:0019221	cytokine-mediated signaling pathway
GO:0031058	positive regulation of histone modification
GO:0033182	regulation of histone ubiquitination
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0045739	positive regulation of DNA repair
GO:0050852	T cell receptor signaling pathway
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051443	positive regulation of ubiquitin-protein transferase activity
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway
GO:0070534	protein K63-linked ubiquitination

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031372	UBC13-MMS2 complex
GO:0035370	UBC13-UEV1A complex
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome