InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TUBG1

Summary

InnateDB Protein

IDBP-51269.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TUBG1

Protein Name

tubulin, gamma 1

Synonyms

CDCBM4; GCP-1; TUBG; TUBGCP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000251413

InnateDB Gene

IDBG-51267 (TUBG1)

Protein Structure

UniProt Annotation

Function

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:9566969}.

Disease Associations

Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4) [MIM:615412]: A disorder of aberrant neuronal migration and disturbed axonal guidance. Clinical features include early-onset seizures, microcephaly, spastic tetraplegia, and various malformations of cortical development, such as agyria, posterior or frontal pachygyria, thick cortex, and subcortical band heterotopia and thin corpus callosum in some patients. {ECO:0000269PubMed:23603762}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 207 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	207 [view]
Protein-Protein	204 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000212	meiotic spindle organization
GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0006184	GTP catabolic process
GO:0007020	microtubule nucleation
GO:0031122	cytoplasmic microtubule organization
GO:0051258	protein polymerization

Cellular Component

GO:0000794	condensed nuclear chromosome
GO:0000930	gamma-tubulin complex
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005827	polar microtubule
GO:0005829	cytosol
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000217 Tubulin
IPR002452 Alpha tubulin
IPR002453 Beta tubulin
IPR002454 Gamma tubulin
IPR002967 Delta tubulin
IPR003008 Tubulin/FtsZ, GTPase domain
IPR004057 Epsilon tubulin
IPR008280 Tubulin/FtsZ, C-terminal
IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
IPR019605 Misato Segment II tubulin-like domain

PFAM

PF00091
PF03953
PF10644

PRINTS

PR01161
PR01162
PR01163
PR01164
PR01224
PR01519

PIRSF

SMART

SM00864
SM00865

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt