InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TUBG1

Summary

InnateDB Gene

IDBG-51267.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TUBG1

Gene Name

tubulin, gamma 1

Synonyms

CDCBM4; GCP-1; TUBG; TUBGCP1

Species

Homo sapiens

Ensembl Gene

ENSG00000131462

Encoded Proteins

IDBP-51269

tubulin, gamma 1

IDBP-758987

IDBP-764581

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:42609676-42615234

Strand

Forward strand

Band

q21.2

Transcripts

ENST00000251413	ENSP00000251413
ENST00000591509	ENSP00000464867
ENST00000588056
ENST00000589688	ENSP00000465582
ENST00000589613

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 207 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	207 [view]
Protein-Protein	204 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000212	meiotic spindle organization
GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0006184	GTP catabolic process
GO:0007020	microtubule nucleation
GO:0031122	cytoplasmic microtubule organization
GO:0051258	protein polymerization

Cellular Component

GO:0000794	condensed nuclear chromosome
GO:0000930	gamma-tubulin complex
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005827	polar microtubule
GO:0005829	cytosol
GO:0005874	microtubule
GO:0043234	protein complex