InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CNTNAP1

Summary

InnateDB Protein

IDBP-51441.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNTNAP1

Protein Name

contactin associated protein 1

Synonyms

CASPR; CNTNAP; NRXN4; P190;

Species

Homo sapiens

Ensembl Protein

ENSP00000264638

InnateDB Gene

IDBG-51437 (CNTNAP1)

Protein Structure

UniProt Annotation

Function

Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding

Biological Process

GO:0002175	protein localization to paranode region of axon
GO:0007010	cytoskeleton organization
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007411	axon guidance
GO:0008088	axon cargo transport
GO:0009967	positive regulation of signal transduction
GO:0019227	neuronal action potential propagation
GO:0030913	paranodal junction assembly
GO:0031175	neuron projection development
GO:0048812	neuron projection morphogenesis
GO:0050884	neuromuscular process controlling posture
GO:0050885	neuromuscular process controlling balance

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0033270	paranode region of axon

Protein Structure and Domains

PDB ID

InterPro

IPR000421 Coagulation factor 5/8 C-terminal type domain
IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR003585 Neurexin/syndecan/glycophorin C
IPR008979 Galactose-binding domain-like
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00754
PF00008
PF00054
PF02210
PF00147

PRINTS

PIRSF

SMART

SM00231
SM00181
SM00210
SM00282
SM00186
SM00294

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P78357