InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMS

Summary

InnateDB Protein

IDBP-51500.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMS

Protein Name

spermine synthase

Synonyms

MRSR; SPMSY; SpS; SRS;

Species

Homo sapiens

Ensembl Protein

ENSP00000368714

InnateDB Gene

IDBG-51494 (SMS)

Protein Structure

UniProt Annotation

Function

Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM).

Subcellular Localization

Disease Associations

X-linked syndromic mental retardation Snyder-Robinson type (MRXSSR) [MIM:309583]: Characterized by moderate intellectual deficit, hypotonia, an unsteady gait, osteoporosis, kyphoscoliosis and facial asymmetry. Transmission is X-linked recessive. {ECO:0000269PubMed:14508504}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004766	spermidine synthase activity
GO:0016768	spermine synthase activity

Biological Process

GO:0006555	methionine metabolic process
GO:0006595	polyamine metabolic process
GO:0006597	spermine biosynthetic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process