InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NRXN1

Summary

InnateDB Protein

IDBP-51551.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRXN1

Protein Name

neurexin 1

Synonyms

Hs.22998; PTHSL2; SCZD17;

Species

Homo sapiens

Ensembl Protein

ENSP00000341184

InnateDB Gene

IDBG-51547 (NRXN1)

Protein Structure

UniProt Annotation

Function

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Note=Localized on the pre- synaptic membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005246	calcium channel regulator activity
GO:0046872	metal ion binding
GO:0048306	calcium-dependent protein binding
GO:0050839	cell adhesion molecule binding
GO:0097109	neuroligin family protein binding

Biological Process

GO:0001525	angiogenesis
GO:0007157	heterophilic cell-cell adhesion
GO:0007158	neuron cell-cell adhesion
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007416	synapse assembly
GO:0007612	learning
GO:0016339	calcium-dependent cell-cell adhesion
GO:0021707	cerebellar granule cell differentiation
GO:0023041	neuronal signal transduction
GO:0030534	adult behavior
GO:0035176	social behavior
GO:0035418	protein localization to synapse
GO:0045184	establishment of protein localization
GO:0051490	negative regulation of filopodium assembly
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0071625	vocalization behavior
GO:0090004	positive regulation of establishment of protein localization to plasma membrane
GO:0090129	positive regulation of synapse maturation
GO:0097091	synaptic vesicle clustering
GO:0097104	postsynaptic membrane assembly
GO:0097105	presynaptic membrane assembly
GO:0097112	gamma-aminobutyric acid receptor clustering
GO:0097114	N-methyl-D-aspartate receptor clustering
GO:0097116	gephyrin clustering
GO:0097117	guanylate kinase-associated protein clustering
GO:0097118	neuroligin clustering
GO:0097119	postsynaptic density protein 95 clustering
GO:0097120	receptor localization to synapse
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000463	positive regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030139	endocytic vesicle
GO:0042734	presynaptic membrane
GO:0044295	axonal growth cone