InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NR1I2

Summary

InnateDB Protein

IDBP-51562.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR1I2

Protein Name

nuclear receptor subfamily 1, group I, member 2

Synonyms

BXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR;

Species

Homo sapiens

Ensembl Protein

ENSP00000336528

InnateDB Gene

IDBG-51560 (NR1I2)

Protein Structure

UniProt Annotation

Function

Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269PubMed:11297522, ECO:0000269PubMed:11668216, ECO:0000269PubMed:12578355, ECO:0000269PubMed:18768384, ECO:0000269PubMed:19297428, ECO:0000269PubMed:9727070}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00407, ECO:0000269PubMed:12606758}.

Disease Associations

Tissue Specificity

Expressed in liver, colon and small intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	51 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0003713	transcription coactivator activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006805	xenobiotic metabolic process
GO:0007165	signal transduction
GO:0008202	steroid metabolic process
GO:0010467	gene expression
GO:0010628	positive regulation of gene expression
GO:0030522	intracellular receptor signaling pathway
GO:0042738	exogenous drug catabolic process
GO:0042908	xenobiotic transport
GO:0043401	steroid hormone mediated signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046618	drug export

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt