InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAMP2

Summary

InnateDB Protein

IDBP-51617.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAMP2

Protein Name

receptor (G protein-coupled) activity modifying protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000253796

InnateDB Gene

IDBG-51615 (RAMP2)

Protein Structure

UniProt Annotation

Function

Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. {ECO:0000269PubMed:22102369, ECO:0000269PubMed:9620797}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Strongly expressed in lung, breast, immune system and fetal tissues. {ECO:0000269PubMed:9620797}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008565	protein transporter activity
GO:0015026	coreceptor activity

Biological Process

GO:0001525	angiogenesis
GO:0001570	vasculogenesis
GO:0001666	response to hypoxia
GO:0002040	sprouting angiogenesis
GO:0006171	cAMP biosynthetic process
GO:0006816	calcium ion transport
GO:0006886	intracellular protein transport
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007507	heart development
GO:0007565	female pregnancy
GO:0008217	regulation of blood pressure
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0010628	positive regulation of gene expression
GO:0015031	protein transport
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031623	receptor internalization
GO:0032355	response to estradiol
GO:0032570	response to progesterone
GO:0032870	cellular response to hormone stimulus
GO:0034333	adherens junction assembly
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0043116	negative regulation of vascular permeability
GO:0045766	positive regulation of angiogenesis
GO:0070830	tight junction assembly
GO:0070831	basement membrane assembly
GO:0072659	protein localization to plasma membrane
GO:0097084	vascular smooth muscle cell development
GO:2000352	negative regulation of endothelial cell apoptotic process
GO:2001214	positive regulation of vasculogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005905	coated pit
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0043235	receptor complex