InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BECN1

Summary

InnateDB Protein

IDBP-51773.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BECN1

Protein Name

beclin 1, autophagy related

Synonyms

ATG6; beclin1; VPS30;

Species

Homo sapiens

Ensembl Protein

ENSP00000355231

InnateDB Gene

IDBG-51769 (BECN1)

Protein Structure

UniProt Annotation

Function

Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. {ECO:0000269PubMed:20208530}.

Subcellular Localization

Golgi apparatus, trans-Golgi network membrane {ECO:0000269PubMed:19050071}; Peripheral membrane protein {ECO:0000269PubMed:19050071}. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 144 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	144 [view]
Protein-Protein	137 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000910	cytokinesis
GO:0006914	autophagy
GO:0006968	cellular defense response
GO:0007040	lysosome organization
GO:0008285	negative regulation of cell proliferation
GO:0016032	viral process
GO:0016239	positive regulation of macroautophagy
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0048666	neuron development
GO:0050435	beta-amyloid metabolic process
GO:0050790	regulation of catalytic activity
GO:0051607	defense response to virus
GO:0051707	response to other organism

Cellular Component

GO:0005737	cytoplasm
GO:0005802	trans-Golgi network
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0043234	protein complex
GO:0045335	phagocytic vesicle