Version 5.4
Homo sapiens Gene: BECN1
Summary
InnateDB Gene IDBG-51769.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BECN1
Gene Name beclin 1, autophagy related
Synonyms ATG6; beclin1; VPS30
Species Homo sapiens
Ensembl Gene ENSG00000126581
Encoded Proteins
IDBP-51773
beclin 1, autophagy related
IDBP-379121
beclin 1, autophagy related
IDBP-762209
IDBP-763735
IDBP-764064
IDBP-762678
IDBP-761281
IDBP-763866
IDBP-763572
IDBP-757667
IDBP-764964
IDBP-762167
IDBP-810853
beclin 1, autophagy related
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18772134
BECN1 is recruited into the mouse Myd88 and Ticam TLR-signalling complex thereby reducing its binding to Bcl2, leading to autophagy.
Entrez Gene
Summary Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42810134-42833350
Strand Reverse strand
Band q21.31
Transcripts
ENST00000361523 ENSP00000355231
ENST00000438274 ENSP00000416173
ENST00000543382
ENST00000590185
ENST00000590764 ENSP00000468597
ENST00000586589 ENSP00000466281
ENST00000585515
ENST00000586754
ENST00000589492
ENST00000590099 ENSP00000465364
ENST00000591307
ENST00000590852 ENSP00000468461
ENST00000589663 ENSP00000468104
ENST00000588276 ENSP00000466419
ENST00000589636 ENSP00000467937
ENST00000593112
ENST00000593205 ENSP00000466766
ENST00000591085 ENSP00000465658
ENST00000589493
ENST00000587880 ENSP00000465964
ENST00000617806
ENST00000612631 ENSP00000479791
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 144 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 144 [view]
Protein-Protein 137 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000910 cytokinesis
GO:0006914 autophagy
GO:0006968 cellular defense response
GO:0007040 lysosome organization
GO:0008285 negative regulation of cell proliferation
GO:0016032 viral process
GO:0016239 positive regulation of macroautophagy
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0048666 neuron development
GO:0050435 beta-amyloid metabolic process
GO:0050790 regulation of catalytic activity
GO:0051607 defense response to virus
GO:0051707 response to other organism
Cellular Component
GO:0005737 cytoplasm
GO:0005802 trans-Golgi network
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0043234 protein complex
GO:0045335 phagocytic vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035086
View Gene Order
ENSBTAG00000019914
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04140
Regulation of autophagy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_003766 XM_005257758
HUGO
OMIM
CCDS CCDS11441
HPRD 05087
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca