InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAF6L

Summary

InnateDB Protein

IDBP-51802.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF6L

Protein Name

TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa

Synonyms

PAF65A;

Species

Homo sapiens

Ensembl Protein

ENSP00000294168

InnateDB Gene

IDBG-51800 (TAF6L)

Protein Structure

UniProt Annotation

Function

Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11564863, ECO:0000269PubMed:9674425}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006325	chromatin organization
GO:0006338	chromatin remodeling
GO:0006352	DNA-templated transcription, initiation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0043966	histone H3 acetylation
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity