InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AOC2

Summary

InnateDB Protein

IDBP-51852.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AOC2

Protein Name

amine oxidase, copper containing 2 (retina-specific)

Synonyms

DAO2; RAO;

Species

Homo sapiens

Ensembl Protein

ENSP00000253799

InnateDB Gene

IDBG-51850 (AOC2)

Protein Structure

UniProt Annotation

Function

Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina. {ECO:0000269PubMed:17400359, ECO:0000269PubMed:19588076}.

Subcellular Localization

Isoform 1: Cell membrane; Peripheral membrane protein. Note=Present on the surface of the cells.Isoform 2: Cytoplasm. Note=Either not translocated to the plasma membrane or below detection level.

Disease Associations

Tissue Specificity

Expressed in many tissues with much higher expression in retina. Isoform 1 and isoform 2 are expressed in adipose tissue, whereas isoform 1 only seems to be present in thymus, and isoform 2 only in testis. {ECO:0000269PubMed:12755418, ECO:0000269PubMed:17400359, ECO:0000269PubMed:19588076}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005507	copper ion binding
GO:0008131	primary amine oxidase activity
GO:0009055	electron carrier activity
GO:0048038	quinone binding
GO:0052593	tryptamine:oxygen oxidoreductase (deaminating) activity
GO:0052594	aminoacetone:oxygen oxidoreductase(deaminating) activity
GO:0052595	aliphatic-amine oxidase activity
GO:0052596	phenethylamine:oxygen oxidoreductase (deaminating) activity

Biological Process

GO:0006584	catecholamine metabolic process
GO:0007601	visual perception
GO:0009308	amine metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000269 Copper amine oxidase
IPR015798 Copper amine oxidase, C-terminal
IPR015800 Copper amine oxidase, N2-terminal
IPR015802 Copper amine oxidase, N3-terminal
IPR016182 Copper amine oxidase, N-terminal

PFAM

PF01179
PF02727
PF02728

PRINTS

PR00766

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O75106