InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LTBP4

Summary

InnateDB Protein

IDBP-51873.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LTBP4

Protein Name

latent transforming growth factor beta binding protein 4

Synonyms

ARCL1C; LTBP-4; LTBP4L; LTBP4S;

Species

Homo sapiens

Ensembl Protein

ENSP00000311905

InnateDB Gene

IDBG-51867 (LTBP4)

Protein Structure

UniProt Annotation

Function

May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM) (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:16157329, ECO:0000269PubMed:9660815}.

Disease Associations

Urban-Rifkin-Davis syndrome (URDS) [MIM:613177]: A syndrome characterized by disrupted pulmonary, gastrointestinal, urinary, musculoskeletal, craniofacial and dermal development. Clinical features include cutis laxa, mild cardiovascular lesions, respiratory distress with cystic and atelectatic changes in the lungs, and diverticulosis, tortuosity and stenosis at various levels of the intestinal tract. Craniofacial features include microretrognathia, flat midface, receding forehead and wide fontanelles. {ECO:0000269PubMed:19836010}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in heart, skeletal muscle, pancreas, uterus, and small intestine. Weakly expressed in placenta and lung. {ECO:0000269PubMed:9271198, ECO:0000269PubMed:9660815}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005539	glycosaminoglycan binding
GO:0050431	transforming growth factor beta binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006457	protein folding
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007275	multicellular organismal development
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0030162	regulation of proteolysis
GO:0030198	extracellular matrix organization
GO:0030252	growth hormone secretion
GO:0045595	regulation of cell differentiation
GO:0046879	hormone secretion

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome