Version 5.4
Homo sapiens Gene: LTBP4
Summary
InnateDB Gene IDBG-51867.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LTBP4
Gene Name latent transforming growth factor beta binding protein 4
Synonyms ARCL1C; LTBP-4; LTBP4L; LTBP4S
Species Homo sapiens
Ensembl Gene ENSG00000090006
Encoded Proteins
IDBP-51869
latent transforming growth factor beta binding protein 4
IDBP-51873
latent transforming growth factor beta binding protein 4
IDBP-51875
latent transforming growth factor beta binding protein 4
IDBP-236670
latent transforming growth factor beta binding protein 4
IDBP-811322
latent transforming growth factor beta binding protein 4
IDBP-811363
latent transforming growth factor beta binding protein 4
IDBP-811305
latent transforming growth factor beta binding protein 4
IDBP-760793
IDBP-811329
latent transforming growth factor beta binding protein 4
IDBP-811361
latent transforming growth factor beta binding protein 4
IDBP-760256
IDBP-760416
IDBP-761035
IDBP-811341
latent transforming growth factor beta binding protein 4
IDBP-811350
latent transforming growth factor beta binding protein 4
IDBP-811358
latent transforming growth factor beta binding protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB is biologically latent after secretion and insertion into the extracellular matrix, and sheds TGFB and other proteins upon activation. Defects in this gene may be a cause of cutis laxa and severe pulmonary, gastrointestinal, and urinary abnormalities. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:40592883-40629818
Strand Forward strand
Band q13.2
Transcripts
ENST00000204005 ENSP00000204005
ENST00000318809
ENST00000308370 ENSP00000311905
ENST00000243562 ENSP00000243562
ENST00000396819 ENSP00000380031
ENST00000546155
ENST00000594116
ENST00000595529
ENST00000599016 ENSP00000482179
ENST00000598256
ENST00000598166 ENSP00000481081
ENST00000593738
ENST00000597151
ENST00000597816
ENST00000600026 ENSP00000483230
ENST00000601032 ENSP00000470824
ENST00000594537 ENSP00000480629
ENST00000594448
ENST00000601464
ENST00000600499
ENST00000598178
ENST00000598717
ENST00000598055
ENST00000595665
ENST00000596351
ENST00000599225 ENSP00000479612
ENST00000599724 ENSP00000469785
ENST00000595118
ENST00000593463 ENSP00000469406
ENST00000597071 ENSP00000472995
ENST00000602251
ENST00000612121 ENSP00000479712
ENST00000610893
ENST00000612845
ENST00000622565
ENST00000618486 ENSP00000480888
ENST00000617753
ENST00000622107
ENST00000622457 ENSP00000478928
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005539 glycosaminoglycan binding
GO:0050431 transforming growth factor beta binding
Biological Process
GO:0001558 regulation of cell growth
GO:0006457 protein folding
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007275 multicellular organismal development
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0030162 regulation of proteolysis
GO:0030198 extracellular matrix organization
GO:0030252 growth hormone secretion
GO:0045595 regulation of cell differentiation
GO:0046879 hormone secretion
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040488
View Gene Order
ENSBTAG00000004757
Not yet available
Pathways
NETPATH
REACTOME
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_118779
Extracellular matrix organization pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.466766
RefSeq NM_001042544 NM_001042545 NM_003573
HUGO
OMIM
CCDS CCDS74368 CCDS74369 CCDS74370
HPRD 05274
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca