InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AOC3

Summary

InnateDB Protein

IDBP-51887.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AOC3

Protein Name

amine oxidase, copper containing 3 (vascular adhesion protein 1)

Synonyms

HPAO; SSAO; VAP-1; VAP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000312326

InnateDB Gene

IDBG-51885 (AOC3)

Protein Structure

UniProt Annotation

Function

Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis. {ECO:0000269PubMed:17400359, ECO:0000269PubMed:19588076, ECO:0000269PubMed:23349812, ECO:0000269PubMed:9653080}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:9653080}; Single-pass type II membrane protein {ECO:0000269PubMed:9653080}.

Disease Associations

Tissue Specificity

Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis. Isoform 2 seems to be the predominant transcript in fetal kidneys, fetal cartilage and fetal tonsils. The highest relative expression of isoform 2 occurs in skeletal muscle, heart, pancreas, kidney, and lung. {ECO:0000269PubMed:17400359, ECO:0000269PubMed:23349812, ECO:0000269PubMed:9653080}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005261	cation channel activity
GO:0005507	copper ion binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008131	primary amine oxidase activity
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0048038	quinone binding
GO:0052593	tryptamine:oxygen oxidoreductase (deaminating) activity
GO:0052594	aminoacetone:oxygen oxidoreductase(deaminating) activity
GO:0052595	aliphatic-amine oxidase activity
GO:0052596	phenethylamine:oxygen oxidoreductase (deaminating) activity

Biological Process

GO:0006812	cation transport
GO:0006954	inflammatory response
GO:0007155	cell adhesion
GO:0009308	amine metabolic process
GO:0046677	response to antibiotic
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0009986	cell surface
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000269 Copper amine oxidase
IPR015798 Copper amine oxidase, C-terminal
IPR015800 Copper amine oxidase, N2-terminal
IPR015802 Copper amine oxidase, N3-terminal
IPR016182 Copper amine oxidase, N-terminal

PFAM

PF01179
PF02727
PF02728

PRINTS

PR00766

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q16853