Version 5.4
Homo sapiens Gene: AOC3
Summary
InnateDB Gene IDBG-51885.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AOC3
Gene Name amine oxidase, copper containing 3 (vascular adhesion protein 1)
Synonyms HPAO; SSAO; VAP-1; VAP1
Species Homo sapiens
Ensembl Gene ENSG00000131471
Encoded Proteins
IDBP-51887
amine oxidase, copper containing 3 (vascular adhesion protein 1)
IDBP-760036
IDBP-758423
IDBP-759037
IDBP-762499
IDBP-813579
amine oxidase, copper containing 3
IDBP-813580
amine oxidase, copper containing 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The product is a major protein on the adipocyte plasma membrane. It has adhesive properties and also has functional monoamine oxidase activity. A pseudogene for this gene has been discribed and is located approximately 9-kb downstream. [provided by RefSeq, Jul 2008]
This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42851184-42858130
Strand Forward strand
Band q21.31
Transcripts
ENST00000308423 ENSP00000312326
ENST00000591562 ENSP00000468632
ENST00000592999 ENSP00000465913
ENST00000588033 ENSP00000468043
ENST00000587330 ENSP00000464787
ENST00000617500 ENSP00000477686
ENST00000613571 ENSP00000484312
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005261 cation channel activity
GO:0005507 copper ion binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008131 primary amine oxidase activity
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0048038 quinone binding
GO:0052593 tryptamine:oxygen oxidoreductase (deaminating) activity
GO:0052594 aminoacetone:oxygen oxidoreductase(deaminating) activity
GO:0052595 aliphatic-amine oxidase activity
GO:0052596 phenethylamine:oxygen oxidoreductase (deaminating) activity
Biological Process
GO:0006812 cation transport
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0009308 amine metabolic process
GO:0046677 response to antibiotic
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019326
View Gene Order
ENSBTAG00000030333
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00360
Phenylalanine metabolism pathway
hsa00260
Glycine, serine and threonine metabolism pathway
hsa00350
Tyrosine metabolism pathway
hsa00410
beta-Alanine metabolism pathway
INOH
INOH website
Tryptophan degradation pathway
INOH website
Phenylalanine degradation pathway
INOH website
Arginine Proline metabolism pathway
INOH website
Tyrosine metabolism pathway
INOH website
Glycine Serine metabolism pathway
INOH website
Histidine degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 8639
UniGene
RefSeq NM_001277731 NM_001277732 NM_003734
HUGO HGNC:550
OMIM 603735
CCDS CCDS74071 CCDS11444 CCDS62198
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 8639

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca