InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPTBN1

Summary

InnateDB Protein

IDBP-51913.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPTBN1

Protein Name

spectrin, beta, non-erythrocytic 1

Synonyms

betaSpII; ELF; HEL102; SPTB2;

Species

Homo sapiens

Ensembl Protein

ENSP00000349259

InnateDB Gene

IDBG-51911 (SPTBN1)

Protein Structure

UniProt Annotation

Function

Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}. Note=Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes. {ECO:0000250}.Isoform 2: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 2 is present in brain, lung and kidney (at protein level). {ECO:0000269PubMed:11665863}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	100 [view]
Protein-Protein	100 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005543	phospholipid binding
GO:0030506	ankyrin binding
GO:0032403	protein complex binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0007009	plasma membrane organization
GO:0007411	axon guidance
GO:0043001	Golgi to plasma membrane protein transport
GO:0051693	actin filament capping
GO:0071709	membrane assembly
GO:0072661	protein targeting to plasma membrane

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0008091	spectrin
GO:0014731	spectrin-associated cytoskeleton
GO:0030673	axolemma
GO:0031430	M band
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001605 Pleckstrin homology domain, spectrin-type
IPR001715 Calponin homology domain
IPR001849 Pleckstrin homology domain
IPR002017 Spectrin repeat
IPR016343 Spectrin, beta subunit
IPR018159 Spectrin/alpha-actinin
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM

PF00307
PF00169
PF00435
PF11971

PRINTS

PR00683

PIRSF

PIRSF002297

SMART

SM00033
SM00233
SM00150

TIGRFAMs

Post-translational Modifications

Modification

Cross-References