InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SPTBN1

Summary

InnateDB Gene

IDBG-51911.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPTBN1

Gene Name

spectrin, beta, non-erythrocytic 1

Synonyms

betaSpII; ELF; HEL102; SPTB2

Species

Homo sapiens

Ensembl Gene

ENSG00000115306

Encoded Proteins

IDBP-51913

spectrin, beta, non-erythrocytic 1

IDBP-51917

spectrin, beta, non-erythrocytic 1

IDBP-51919

spectrin, beta, non-erythrocytic 1

IDBP-812582

spectrin, beta, non-erythrocytic 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:54456285-54671445

Strand

Forward strand

Band

p16.2

Transcripts

ENST00000356805	ENSP00000349259
ENST00000389980	ENSP00000374630
ENST00000333896	ENSP00000334156
ENST00000496323
ENST00000467371
ENST00000602898
ENST00000615901	ENSP00000479037

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	100 [view]
Protein-Protein	100 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005543	phospholipid binding
GO:0030506	ankyrin binding
GO:0032403	protein complex binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0007009	plasma membrane organization
GO:0007411	axon guidance
GO:0043001	Golgi to plasma membrane protein transport
GO:0051693	actin filament capping
GO:0071709	membrane assembly
GO:0072661	protein targeting to plasma membrane

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0008091	spectrin
GO:0014731	spectrin-associated cytoskeleton
GO:0030673	axolemma
GO:0031430	M band
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome