Version 5.4
Homo sapiens Protein: ZNF645
Summary
InnateDB Protein IDBP-51928.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZNF645
Protein Name zinc finger protein 645
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000323348
InnateDB Gene IDBG-51924 (ZNF645)
Protein Structure
UniProt Annotation
Function E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates. {ECO:0000269PubMed:22252131}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:20657603}. Note=Localized over the postacrosomal perinuclear theca region and the entire length of sperm tail.
Disease Associations
Tissue Specificity Exclusively expressed in testis and sperm, including spermatocytes, round and elongated spermatids, and Leydig cells. {ECO:0000269PubMed:20657603}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR007087 Zinc finger, C2H2
PFAM PF13639
PF14634
PF00096
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N7E2
PhosphoSite PhosphoSite-Q8N7E2
TrEMBL
UniProt Splice Variant
Entrez Gene 158506
UniGene Hs.132485
RefSeq NP_689790
HUGO HGNC:26371
OMIM
CCDS CCDS14205
HPRD 06545
IMGT
EMBL AK098601 BC074910 BC126190 BC126192 BX293560
GenPept AAH74910 AAI26191 AAI26193 BAC05348 CAI40652

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca