InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GTF2E1

Summary

InnateDB Protein

IDBP-51931.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GTF2E1

Protein Name

general transcription factor IIE, polypeptide 1, alpha 56kDa

Synonyms

FE; TF2E1; TFIIE-A;

Species

Homo sapiens

Ensembl Protein

ENSP00000283875

InnateDB Gene

IDBG-51929 (GTF2E1)

Protein Structure

UniProt Annotation

Function

Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	59 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0016032	viral process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0045111	intermediate filament cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR002853 Transcription factor TFIIE, alpha subunit
IPR013137 Zinc finger, TFIIB-type
IPR021600 Transcription factor TFIIE alpha subunit, C-terminal
IPR024550 TFIIEalpha/SarR/Rpc3 HTH domain

PFAM

PF08271
PF11521
PF02002

PRINTS

PIRSF

SMART

SM00531

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P29083