InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AARSD1

Summary

InnateDB Protein

IDBP-51973.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AARSD1

Protein Name

alanyl-tRNA synthetase domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000353355

InnateDB Gene

IDBG-51971 (AARSD1)

Protein Structure

UniProt Annotation

Function

Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003674	molecular_function
GO:0003676	nucleic acid binding
GO:0004813	alanine-tRNA ligase activity
GO:0005524	ATP binding
GO:0016876	ligase activity, forming aminoacyl-tRNA and related compounds
GO:0046872	metal ion binding

Biological Process

GO:0006419	alanyl-tRNA aminoacylation
GO:0008150	biological_process
GO:0043039	tRNA aminoacylation

Cellular Component

GO:0005575	cellular_component
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR007052 CS domain
IPR008978 HSP20-like chaperone
IPR012947 Threonyl/alanyl tRNA synthetase, SAD
IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain
IPR018164 Alanyl-tRNA synthetase, class IIc, N-terminal
IPR018165 Alanyl-tRNA synthetase, class IIc, core domain

PFAM

PF04969
PF07973
PF01411

PRINTS

PIRSF

SMART

SM00863

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BTE6