InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SH3GL2

Summary

InnateDB Protein

IDBP-51985.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SH3GL2

Protein Name

SH3-domain GRB2-like 2

Synonyms

CNSA2; EEN-B1; SH3D2A; SH3P4;

Species

Homo sapiens

Ensembl Protein

ENSP00000369981

InnateDB Gene

IDBG-51983 (SH3GL2)

Protein Structure

UniProt Annotation

Function

Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein. Note=Concentrated in presynaptic nerve terminals in neurons.

Disease Associations

Tissue Specificity

Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 112 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	112 [view]
Protein-Protein	112 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0042802	identical protein binding

Biological Process

GO:0002090	regulation of receptor internalization
GO:0006892	post-Golgi vesicle-mediated transport
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007411	axon guidance
GO:0007417	central nervous system development
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048488	synaptic vesicle endocytosis
GO:0061024	membrane organization

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR004148 BAR domain
IPR011511 Variant SH3 domain
IPR013315 Spectrin alpha chain, SH3 domain
IPR018859 BAR domain-containing family

PFAM

PF00018
PF14604
PF03114
PF07653
PF10455

PRINTS

PR00452
PR01887

PIRSF

SMART

SM00326
SM00721

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt