InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POU4F3

Summary

InnateDB Protein

IDBP-52036.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POU4F3

Protein Name

POU class 4 homeobox 3

Synonyms

BRN3C; DFNA15;

Species

Homo sapiens

Ensembl Protein

ENSP00000230732

InnateDB Gene

IDBG-52034 (POU4F3)

Protein Structure

UniProt Annotation

Function

May play a role in determining or maintaining the identities of a small subset of visual system neurons.

Subcellular Localization

Nucleus.

Disease Associations

Deafness, autosomal dominant, 15 (DFNA15) [MIM:602459]: A form of non-syndromic hearing loss with variable phenotype in terms of age at onset, levels of progression, and shape of audiograms. {ECO:0000269PubMed:18228599, ECO:0000269PubMed:9506947}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Brain. Seems to be specific to the retina. {ECO:0000269PubMed:7623109, ECO:0000269PubMed:9506947}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007601	visual perception
GO:0007605	sensory perception of sound
GO:0021562	vestibulocochlear nerve development
GO:0031290	retinal ganglion cell axon guidance
GO:0042472	inner ear morphogenesis
GO:0042491	auditory receptor cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048675	axon extension
GO:0048839	inner ear development
GO:0050885	neuromuscular process controlling balance
GO:0051402	neuron apoptotic process
GO:0060113	inner ear receptor cell differentiation