InnateDB Protein
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IDBP-52149.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SNRPA
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Protein Name
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small nuclear ribonucleoprotein polypeptide A
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Synonyms
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Mud1; U1-A; U1A;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000243563
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InnateDB Gene
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IDBG-52147 (SNRPA)
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Protein Structure
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Function |
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs. {ECO:0000269PubMed:9848648}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
P09012
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PhosphoSite |
PhosphoSite-P09012
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TrEMBL |
M0R2B8
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UniProt Splice Variant |
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Entrez Gene |
6626
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UniGene |
Hs.466775
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RefSeq |
NP_004587
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HUGO |
HGNC:11151
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OMIM |
182285
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CCDS |
CCDS12565
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HPRD |
01658
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IMGT |
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EMBL |
AC020945
BC000405
BC008290
M60779
M60780
M60781
M60782
M60783
M60784
X06347
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GenPept |
AAA61245
AAH00405
AAH08290
CAA29653
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