Version 5.4
Homo sapiens Protein: EAF2
Summary
InnateDB Protein IDBP-52227.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EAF2
Protein Name ELL associated factor 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000273668
InnateDB Gene IDBG-52225 (EAF2)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo. {ECO:0000250, ECO:0000269PubMed:12446457, ECO:0000269PubMed:12907652, ECO:0000269PubMed:16006523}.
Subcellular Localization Nucleus speckle {ECO:0000269PubMed:12446457, ECO:0000269PubMed:12907652}. Note=Colocalizes with ELL to nuclear speckles.
Disease Associations
Tissue Specificity Expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, prostate, testis, small intestine, colon, adrenal, bone marrow, lymph node, spinal gland, stomach, thyroid, trachea, thymus, liver and leukocytes. {ECO:0000269PubMed:12446457, ECO:0000269PubMed:12907652}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
GO:0030308 negative regulation of cell growth
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development
Cellular Component
GO:0005654 nucleoplasm
GO:0016607 nuclear speck
GO:0032783 ELL-EAF complex
Protein Structure and Domains
PDB ID
InterPro IPR019194 Transcription elognation factor Eaf, N-terminal
PFAM PF09816
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96CJ1
PhosphoSite PhosphoSite-Q96CJ1
TrEMBL F8WF04
UniProt Splice Variant
Entrez Gene 55840
UniGene Hs.732120
RefSeq NP_060926
HUGO HGNC:23115
OMIM 607659
CCDS CCDS3006
HPRD 09634
IMGT
EMBL AC072031 AC119736 AF217516 AF517829 AY049020 BC014209
GenPept AAF67627 AAH14209 AAL12223 AAO63811

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca