Version 5.4
Homo sapiens Protein: SPINK6
Summary
InnateDB Protein IDBP-52423.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPINK6
Protein Name serine peptidase inhibitor, Kazal type 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000324870
InnateDB Gene IDBG-52421 (SPINK6)
Protein Structure
UniProt Annotation
Function Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8. {ECO:0000269PubMed:20667819, ECO:0000269PubMed:21439340}.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR002350 Kazal domain
PFAM PF00050
PF07648
PRINTS
PIRSF
SMART SM00280
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UWN8
PhosphoSite PhosphoSite-
TrEMBL D6RGX9
UniProt Splice Variant
Entrez Gene 404203
UniGene Hs.334274
RefSeq NP_995313
HUGO HGNC:29486
OMIM 615868
CCDS CCDS34268
HPRD 15439
IMGT
EMBL AC011346 AY358716 BC032003 CH471062 GQ504704 GQ504705
GenPept AAH32003 AAQ89078 ADM46526 ADM46527 EAW61813

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca