InnateDB Protein
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IDBP-52432.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CCDC88A
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Protein Name
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coiled-coil domain containing 88A
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000338728
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InnateDB Gene
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IDBG-52430 (CCDC88A)
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Protein Structure
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Function |
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome. {ECO:0000250, ECO:0000269PubMed:15882442, ECO:0000269PubMed:16139227}.
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Subcellular Localization |
Membrane {ECO:0000269PubMed:15882442, ECO:0000269PubMed:16139227}. Cell membrane {ECO:0000269PubMed:15882442, ECO:0000269PubMed:16139227}. Cytoplasm, cytosol. Cytoplasmic vesicle {ECO:0000269PubMed:15882442, ECO:0000269PubMed:16139227}. Cell projection, lamellipodium. Note=Localizes to the cell membrane through interaction with phosphoinositides. {ECO:0000269PubMed:15882442, ECO:0000269PubMed:16139227}.
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Disease Associations |
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Tissue Specificity |
Expressed ubiquitously. {ECO:0000269PubMed:16139227}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
22
[view]
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Protein-Protein |
22
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR008636
Hook-related protein family
IPR009053
Prefoldin
IPR010989
t-SNARE
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PFAM |
PF05622
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3V6T2
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PhosphoSite |
PhosphoSite-Q3V6T2
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TrEMBL |
C9J225
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UniProt Splice Variant |
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Entrez Gene |
55704
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UniGene |
Hs.620023
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RefSeq |
NP_001129069
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HUGO |
HGNC:25523
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OMIM |
609736
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CCDS |
CCDS46288
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HPRD |
11131
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IMGT |
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EMBL |
AB125644
AB201172
AC012358
AC019198
AC092176
AK299823
BC132736
BC144320
BX537985
BX538154
BX648138
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GenPept |
AAI32737
AAI44321
AAX82029
AAY14932
BAE44387
BAF44475
BAG61692
CAD97945
CAD98038
CAI46020
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