InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCDC88A

Summary

InnateDB Protein

IDBP-52434.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCDC88A

Protein Name

coiled-coil domain containing 88A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000263630

InnateDB Gene

IDBG-52430 (CCDC88A)

Protein Structure

UniProt Annotation

Function

Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome. {ECO:0000250, ECO:0000269PubMed:15882442, ECO:0000269PubMed:16139227}.

Subcellular Localization

Membrane {ECO:0000269PubMed:15882442, ECO:0000269PubMed:16139227}. Cell membrane {ECO:0000269PubMed:15882442, ECO:0000269PubMed:16139227}. Cytoplasm, cytosol. Cytoplasmic vesicle {ECO:0000269PubMed:15882442, ECO:0000269PubMed:16139227}. Cell projection, lamellipodium. Note=Localizes to the cell membrane through interaction with phosphoinositides. {ECO:0000269PubMed:15882442, ECO:0000269PubMed:16139227}.

Disease Associations

Tissue Specificity

Expressed ubiquitously. {ECO:0000269PubMed:16139227}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0008017	microtubule binding
GO:0035091	phosphatidylinositol binding
GO:0042803	protein homodimerization activity
GO:0043422	protein kinase B binding

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0006260	DNA replication
GO:0006275	regulation of DNA replication
GO:0010975	regulation of neuron projection development
GO:0016192	vesicle-mediated transport
GO:0016477	cell migration
GO:0030032	lamellipodium assembly
GO:0031929	TOR signaling
GO:0032148	activation of protein kinase B activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0042127	regulation of cell proliferation
GO:0045087	innate immune response (InnateDB)
GO:0061024	membrane organization

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030027	lamellipodium
GO:0031410	cytoplasmic vesicle