InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAF3

Summary

InnateDB Protein

IDBP-52501.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF3

Protein Name

TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000340271

InnateDB Gene

IDBG-52499 (TAF3)

Protein Structure

UniProt Annotation

Function

Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11438666}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0051457	maintenance of protein location in nucleus

Cellular Component

GO:0005634	nucleus
GO:0005669	transcription factor TFIID complex

Protein Structure and Domains

PDB ID

InterPro

IPR001965 Zinc finger, PHD-type
IPR006565 Bromodomain transcription factor
IPR009072 Histone-fold
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger

PFAM

PF07524
PF00628

PRINTS

PIRSF

SMART

SM00249
SM00576

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5VWG9