InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TAF3

Summary

InnateDB Gene

IDBG-52499.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF3

Gene Name

TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000165632

Encoded Proteins

IDBP-52501

TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).[supplied by OMIM, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:7818504-8016627

Strand

Forward strand

Band

p14

Transcripts

ENST00000344293

ENSP00000340271

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0051457	maintenance of protein location in nucleus