InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP2A13

Summary

InnateDB Protein

IDBP-52507.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP2A13

Protein Name

cytochrome P450, family 2, subfamily A, polypeptide 13

Synonyms

CPAD; CYP2A; CYPIIA13;

Species

Homo sapiens

Ensembl Protein

ENSP00000332679

InnateDB Gene

IDBG-52505 (CYP2A13)

Protein Structure

UniProt Annotation

Function

Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N- dimethylaniline, 2'-methoxyacetophenone, N- nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity. {ECO:0000269PubMed:18779312}.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Expressed in liver and a number of extrahepatic tissues, including nasal mucosa, lung, trachea, brain, mammary gland, prostate, testis, and uterus, but not in heart, kidney, bone marrow, colon, small intestine, spleen, stomach, thymus, or skeletal muscle. {ECO:0000269PubMed:11016631}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0070330	aromatase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005789

endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
IPR008067 Cytochrome P450, E-class, group I, CYP2A-like

PFAM

PF00067

PRINTS

PR00385
PR00463
PR00465
PR01684

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q16696