InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GATA3

Summary

InnateDB Protein

IDBP-52617.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GATA3

Protein Name

GATA binding protein 3

Synonyms

HDR; HDRS;

Species

Homo sapiens

Ensembl Protein

ENSP00000368632

InnateDB Gene

IDBG-52615 (GATA3)

Protein Structure

UniProt Annotation

Function

Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. {ECO:0000269PubMed:23824597}.

Subcellular Localization

Nucleus.

Disease Associations

Hypoparathyroidism, sensorineural deafness, and renal disease (HDR) [MIM:146255]: A disease characterized by steroid- resistant nephrosis with progressive renal failure, hypoparathyroidism, sensorineural deafness, and renal dysplasia. {ECO:0000269PubMed:10935639, ECO:0000269PubMed:11389161}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

T-cells and endothelial cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	68 [view]
Protein-Protein	25 [view]
Protein-DNA	42 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0001046	core promoter sequence-specific DNA binding
GO:0001071	nucleic acid binding transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001158	enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005134	interleukin-2 receptor binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046983	protein dimerization activity
GO:0070888	E-box binding
GO:0071837	HMG box domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000902	cell morphogenesis
GO:0001701	in utero embryonic development
GO:0001709	cell fate determination
GO:0001764	neuron migration
GO:0001775	cell activation
GO:0001806	type IV hypersensitivity
GO:0001819	positive regulation of cytokine production
GO:0001822	kidney development
GO:0001823	mesonephros development
GO:0002088	lens development in camera-type eye
GO:0002572	pro-T cell differentiation
GO:0003180	aortic valve morphogenesis
GO:0003215	cardiac right ventricle morphogenesis
GO:0003281	ventricular septum development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006952	defense response
GO:0006959	humoral immune response
GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0008285	negative regulation of cell proliferation
GO:0008584	male gonad development
GO:0009615	response to virus
GO:0009653	anatomical structure morphogenesis
GO:0009791	post-embryonic development
GO:0009967	positive regulation of signal transduction
GO:0010332	response to gamma radiation
GO:0010595	positive regulation of endothelial cell migration
GO:0010629	negative regulation of gene expression
GO:0010975	regulation of neuron projection development
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0030182	neuron differentiation
GO:0030217	T cell differentiation
GO:0030218	erythrocyte differentiation
GO:0031929	TOR signaling
GO:0032689	negative regulation of interferon-gamma production
GO:0032703	negative regulation of interleukin-2 production
GO:0032736	positive regulation of interleukin-13 production
GO:0032753	positive regulation of interleukin-4 production
GO:0032754	positive regulation of interleukin-5 production
GO:0033077	T cell differentiation in thymus
GO:0033600	negative regulation of mammary gland epithelial cell proliferation
GO:0035162	embryonic hemopoiesis
GO:0035457	cellular response to interferon-alpha
GO:0035799	ureter maturation
GO:0035898	parathyroid hormone secretion
GO:0042035	regulation of cytokine biosynthetic process
GO:0042421	norepinephrine biosynthetic process
GO:0042472	inner ear morphogenesis
GO:0042493	response to drug
GO:0043370	regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043523	regulation of neuron apoptotic process
GO:0043583	ear development
GO:0043627	response to estrogen
GO:0045061	thymic T cell selection
GO:0045064	T-helper 2 cell differentiation
GO:0045087	innate immune response
GO:0045471	response to ethanol
GO:0045582	positive regulation of T cell differentiation
GO:0045597	positive regulation of cell differentiation
GO:0045599	negative regulation of fat cell differentiation
GO:0045786	negative regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048469	cell maturation
GO:0048485	sympathetic nervous system development
GO:0048538	thymus development
GO:0048568	embryonic organ development
GO:0048589	developmental growth
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048872	homeostasis of number of cells
GO:0050728	negative regulation of inflammatory response
GO:0050852	T cell receptor signaling pathway
GO:0051569	regulation of histone H3-K4 methylation
GO:0051897	positive regulation of protein kinase B signaling
GO:0060017	parathyroid gland development
GO:0060037	pharyngeal system development
GO:0060065	uterus development
GO:0060231	mesenchymal to epithelial transition
GO:0060374	mast cell differentiation
GO:0060676	ureteric bud formation
GO:0061085	regulation of histone H3-K27 methylation
GO:0061290	canonical Wnt signaling pathway involved in metanephric kidney development
GO:0071345	cellular response to cytokine stimulus
GO:0071353	cellular response to interleukin-4
GO:0071356	cellular response to tumor necrosis factor
GO:0071599	otic vesicle development
GO:0071773	cellular response to BMP stimulus
GO:0072001	renal system development
GO:0072107	positive regulation of ureteric bud formation
GO:0072178	nephric duct morphogenesis
GO:0072179	nephric duct formation
GO:0072182	regulation of nephron tubule epithelial cell differentiation
GO:0072602	interleukin-4 secretion
GO:0072643	interferon-gamma secretion
GO:0072676	lymphocyte migration
GO:2000114	regulation of establishment of cell polarity
GO:2000146	negative regulation of cell motility
GO:2000352	negative regulation of endothelial cell apoptotic process
GO:2000607	negative regulation of cell proliferation involved in mesonephros development
GO:2000611	positive regulation of thyroid hormone generation
GO:2000664	positive regulation of interleukin-5 secretion
GO:2000667	positive regulation of interleukin-13 secretion
GO:2000679	positive regulation of transcription regulatory region DNA binding
GO:2000683	regulation of cellular response to X-ray
GO:2000703	negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
GO:2000734	negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation