InnateDB Protein
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IDBP-52645.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DENND4C
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Protein Name
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DENN/MADD domain containing 4C
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000369789
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InnateDB Gene
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IDBG-52631 (DENND4C)
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Protein Structure
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Function |
Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269PubMed:20937701}.
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Subcellular Localization |
Cytoplasmic vesicle membrane. Cell membrane. Cytoplasm, cytosol. Note=Associates with SLC2A4/GLUT4 storage vesicles.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
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PhosphoSite |
PhosphoSite-Q5VZ89
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55667
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UniGene |
Hs.701821
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RefSeq |
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HUGO |
HGNC:26079
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OMIM |
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CCDS |
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HPRD |
12927
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IMGT |
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EMBL |
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GenPept |
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