Version 5.4
Homo sapiens Protein: MEOX1
Summary
InnateDB Protein IDBP-52862.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MEOX1
Protein Name mesenchyme homeobox 1
Synonyms KFS2; MOX1;
Species Homo sapiens
Ensembl Protein ENSP00000328678
InnateDB Gene IDBG-52858 (MEOX1)
Protein Structure
UniProt Annotation
Function Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.
Disease Associations Klippel-Feil syndrome 2, autosomal recessive (KFS2) [MIM:214300]: A skeletal disorder characterized by congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of fetal development. The clinical triad consists of short neck, low posterior hairline, and limited neck movement. {ECO:0000269PubMed:23290072}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0007275 multicellular organismal development
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P50221
PhosphoSite PhosphoSite-P50221
TrEMBL
UniProt Splice Variant
Entrez Gene 4222
UniGene Hs.438
RefSeq NP_054705
HUGO HGNC:7013
OMIM 600147
CCDS CCDS11467
HPRD 02537
IMGT
EMBL AC004149 AC068675 BC069474 BC069506 CH471178 U10492 U10493
GenPept AAA19983 AAA19984 AAH69474 AAH69506 EAW51672

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca