Version 5.4
Homo sapiens Protein: PDIA5
Summary
InnateDB Protein IDBP-52868.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDIA5
Protein Name protein disulfide isomerase family A, member 5
Synonyms PDIR;
Species Homo sapiens
Ensembl Protein ENSP00000323313
InnateDB Gene IDBG-52866 (PDIA5)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000255PROSITE-ProRule:PRU10138}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003756 protein disulfide isomerase activity
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006457 protein folding
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0034976 response to endoplasmic reticulum stress
GO:0044267 cellular protein metabolic process
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID
InterPro IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain
PFAM PF00578
PF13098
PF13192
PF13462
PF13905
PF00085
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14554
PhosphoSite PhosphoSite-Q14554
TrEMBL C9JY10
UniProt Splice Variant
Entrez Gene 10954
UniGene Hs.477352
RefSeq NP_006801
HUGO HGNC:24811
OMIM
CCDS CCDS3020
HPRD 08334
IMGT
EMBL AC063922 AC083797 CH471052 D49490
GenPept BAA08451 EAW79452 EAW79454

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca