InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC24A2

Summary

InnateDB Protein

IDBP-52999.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC24A2

Protein Name

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

Synonyms

NCKX2;

Species

Homo sapiens

Ensembl Protein

ENSP00000344801

InnateDB Gene

IDBG-52997 (SLC24A2)

Protein Structure

UniProt Annotation

Function

Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005262	calcium channel activity
GO:0005509	calcium ion binding
GO:0008273	calcium, potassium:sodium antiporter activity
GO:0015293	symporter activity
GO:0016151	nickel cation binding
GO:0030145	manganese ion binding
GO:0030955	potassium ion binding
GO:0031402	sodium ion binding
GO:0046870	cadmium ion binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0007601	visual perception
GO:0007612	learning
GO:0007613	memory
GO:0034220	ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport
GO:0060291	long-term synaptic potentiation
GO:0060292	long term synaptic depression
GO:0070588	calcium ion transmembrane transport