InnateDB Protein
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IDBP-53001.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC24A2
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Protein Name
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solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
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Synonyms
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NCKX2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000286344
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InnateDB Gene
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IDBG-52997 (SLC24A2)
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Protein Structure
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Function |
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).
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Subcellular Localization |
Membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0008273
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calcium, potassium:sodium antiporter activity
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GO:0015293
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symporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004481
Sodium/potassium/calcium exchanger
IPR004837
Sodium/calcium exchanger membrane region
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PFAM |
PF01699
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UI40
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PhosphoSite |
PhosphoSite-Q9UI40
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
25769
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UniGene |
Hs.283014
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RefSeq |
NP_001180217
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HUGO |
HGNC:10976
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OMIM |
609838
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CCDS |
CCDS55297
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HPRD |
15351
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IMGT |
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EMBL |
AF097366
AF177987
AL133281
AL158077
AL158206
BC069622
BC143889
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GenPept |
AAF21810
AAF25811
AAH69622
AAI43890
CAH71736
CAH71737
CAH73020
CAH73021
CAH74108
CAH74109
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