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InnateDB Protein
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IDBP-53034.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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USP6NL
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Protein Name
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USP6 N-terminal like
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Synonyms
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RNTRE; TRE2NL; USP6NL-IT1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000368539
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InnateDB Gene
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IDBG-53032 (USP6NL)
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Protein Structure
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| Function |
Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269PubMed:11099046, ECO:0000269PubMed:17562788, ECO:0000269PubMed:17684057}.
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| Subcellular Localization |
Golgi apparatus. Cytoplasmic vesicle.
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| Disease Associations |
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| Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:8700515}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
6
[view]
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| Protein-Protein |
6
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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Molecular Function |
| Accession |
GO Term |
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GO:0005097
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Rab GTPase activator activity
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| Biological Process |
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR000195
Rab-GTPase-TBC domain
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| PFAM |
PF00566
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| PRINTS |
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| PIRSF |
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| SMART |
SM00164
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q92738
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| TrEMBL |
X6RAB3
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| UniProt Splice Variant |
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| Entrez Gene |
9712
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| UniGene |
Hs.618487
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| RefSeq |
XP_006717605
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| HUGO |
HGNC:16858
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| OMIM |
605405
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AL512631
AL590416
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| GenPept |
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Version 5.4