InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USP6NL

Summary

InnateDB Protein

IDBP-53036.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP6NL

Protein Name

USP6 N-terminal like

Synonyms

RNTRE; TRE2NL; USP6NL-IT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000277575

InnateDB Gene

IDBG-53032 (USP6NL)

Protein Structure

UniProt Annotation

Function

Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. {ECO:0000269PubMed:11099046, ECO:0000269PubMed:17562788, ECO:0000269PubMed:17684057}.

Subcellular Localization

Golgi apparatus. Cytoplasmic vesicle.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:8700515}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005097	Rab GTPase activator activity

Biological Process

GO:0007030	Golgi organization
GO:0032313	regulation of Rab GTPase activity
GO:0032851	positive regulation of Rab GTPase activity
GO:0035526	retrograde transport, plasma membrane to Golgi