InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PAPOLG

Summary

InnateDB Protein

IDBP-53071.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAPOLG

Protein Name

poly(A) polymerase gamma

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000238714

InnateDB Gene

IDBG-53069 (PAPOLG)

Protein Structure

UniProt Annotation

Function

Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269PubMed:11287430, ECO:0000269PubMed:11463842}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11287430, ECO:0000269PubMed:11463842}.

Disease Associations

Tissue Specificity

Expressed predominantly in testis, and weakly in other tissues. Overexpressed in several tumors. {ECO:0000269PubMed:11463842}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004652	polynucleotide adenylyltransferase activity
GO:0005524	ATP binding
GO:0016779	nucleotidyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006378	mRNA polyadenylation
GO:0031123	RNA 3'-end processing
GO:0043631	RNA polyadenylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002934 Nucleotidyl transferase domain
IPR007010 Poly(A) polymerase, RNA-binding domain
IPR007012 Poly(A) polymerase, central domain
IPR011068 Nucleotidyltransferase, class I, C-terminal-like
IPR014492 Poly(A) polymerase

PFAM

PF01909
PF04926
PF04928

PRINTS

PIRSF

PIRSF018425

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BWT3