Version 5.4
Homo sapiens Gene: PAPOLG
Summary
InnateDB Gene IDBG-53069.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAPOLG
Gene Name poly(A) polymerase gamma
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000115421
Encoded Proteins
IDBP-53071
poly(A) polymerase gamma
IDBP-376948
poly(A) polymerase gamma
IDBP-376949
poly(A) polymerase gamma
IDBP-376950
poly(A) polymerase gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:60756230-60802085
Strand Forward strand
Band p16.1
Transcripts
ENST00000238714 ENSP00000238714
ENST00000414060 ENSP00000405599
ENST00000453839 ENSP00000414070
ENST00000412217 ENSP00000405570
ENST00000496283
ENST00000483370
ENST00000470208
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0004652 polynucleotide adenylyltransferase activity
GO:0005524 ATP binding
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006378 mRNA polyadenylation
GO:0031123 RNA 3'-end processing
GO:0043631 RNA polyadenylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020273
View Gene Order
ENSBTAG00000007414
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H7C3W0
UniProt Splice Variant
Entrez Gene 64895
UniGene Hs.697385
RefSeq NM_022894 XM_005264500 XM_005264501
HUGO HGNC:14982
OMIM
CCDS CCDS1863
HPRD 11420
IMGT
EMBL AC011245 AC012498
GenPept
RNA Seq Atlas 64895

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca